The topography of Lusby is typical of the mid-Atlantic coastal plain: generally flat to gently rolling, with elevations rarely exceeding 100 feet above sea level.
The eastern edge of the greater Lusby area drops dramatically into the Chesapeake Bay at Calvert Cliffs, where erosion continually exposes layers of prehistoric sediment. Inland, the terrain is interspersed with numerous tidal creeks and deep ravines that drain into the Patuxent River and the Bay. The lowest points are at sea level along the shoreline and tidal marshes, while the highest points are situated along the central spine of the peninsula where the main highway (Route 2/4) runs.

