Milpitas is home to numerous corporate headquarters and major regional offices:
* **KLA Corporation:** A prominent capital equipment company headquartered in Milpitas. * **Cisco Systems:** Operates large campuses and offices within the city's tech-park districts. * **Flex (Flextronics):** Maintains a significant regional hub and operational presence in the city. * **Western Digital / SanDisk:** Major manufacturing and R&D operations located in Milpitas.