Sprendlingen and the wider Dreieich area have been home to several notable figures:
* **Johann Philipp Holzmann (1805–1870):** Born in Sprendlingen, he founded the Philipp Holzmann AG, which grew to become one of Germany's largest construction companies. * **Horst Schmidt (1925–1976):** A prominent German politician (SPD) and former Hessian Minister for Social Affairs, who lived and worked in the area. * **Josef Neckermann (1912–1992):** The famous German equestrian and founder of the Neckermann mail-order company lived on a notable estate nearby, deeply influencing the local economy of the region.